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Brain Res Mol Brain Res. 1993 Sep;19(4):339-44.

Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain.

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Department of Biochemistry and Molecular Biology, Kenneth Norris Jr. Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033.


In this report, we demonstrate that the brain-specific ras nucleotide-exchange factor, cdc25NEF-B, is expressed in specific neuronal populations in the juvenile rat brain. Because cdc25NEF-B likely regulates one or more of the vertebrate ras proteins, H-, K- and N-ras, we also examined their levels of expression and pattern of expression in the juvenile rat brain. We find cdc25NEF-B to be highly expressed in the hippocampus, some deep nuclei, neocortex, and the granule cell layer of the anterior lobules of the cerebellum. Our observations suggest a functional link between cdc25NEF-B and H-ras in a neuronal signal transduction pathway.

[Indexed for MEDLINE]

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