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Kurume Med J. 1993;40(2):65-7.

Low-dose/long-term erythromycin for treatment of bronchiolitis obliterans organizing pneumonia (BOOP).

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1
Department of Medicine, Kurume University School of Medicine, Japan.

Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic entity characterized by intraluminal fibrosis of distal air spaces. Corticosteroids have been widely used for the treatment of this condition, and most patients showed a dramatic response to it. However, long-term treatment with corticosteroids, which often increases the risk of several undesirable side-effects, is usually required because a relapse tends to occur soon after termination of treatment. We administered erythromycin (EM) at low-dose (600 mg daily) for 3-4 months to 6 patients with BOOP, and obtained a good clinical, radiological, and physiological improvement. This suggests that EM can be successfully used, instead of corticosteroids, in the treatment of BOOP.

PMID:
8231065
DOI:
10.2739/kurumemedj.40.65
[Indexed for MEDLINE]
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