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J Rheumatol. 1993 Aug;20(8):1383-5.

Withdrawal of longterm antihyperuricemic therapy in tophaceous gout.

Author information

1
Department of Rheumatology, University Hospital, Leiden, The Netherlands.

Abstract

OBJECTIVE:

To determine the effect of withdrawal of antihyperuricemic therapy on the recurrence of tophi and acute arthritis.

METHODS:

We performed a retrospective investigation of 21 patients with tophaceous gout who stopped therapy because they had no arthritis for years, and on examination tophi had disappeared.

RESULTS:

Nine patients (43%) had a recurrence of tophi after an average period of 39.6 months (range 4-107 months). Seventeen patients (81%) had attacks of acute arthritis, 6 patients within 6 months. During a mean period of drug discontinuation of 37.6 months no increase in serum creatinine or deterioration in joint function was observed.

CONCLUSION:

Based on our data we conclude that intermittent usage of antihyperuricemic drugs will, after a variable period, result in the frequent recurrence of acute arthritis and tophi.

PMID:
8230024
[Indexed for MEDLINE]

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