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Immunol Rev. 1993 Jun;133:177-97.

Molecular regulation of the IL-2 gene: rheostatic control of the immune system.

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Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.


The delivery of costimulation and the effects of the anergic state impinge on IL-2 production via different molecular mechanisms. The strongest experimental support at this stage suggests that CD28 signaling effects mRNA stability of several lymphokine genes including IL-2. While there may also be transcriptional effects of CD28 signals in human cells, controversy surrounding relevant TCR mimics must be addressed. In the case of clonal anergy, however, transcriptional non-responsiveness is evident when anergic cells are restimulated with TCR and costimulatory signals. This repression affects predominantly AP-1 activity. So far, the nature of the repression has not been identified.

[Indexed for MEDLINE]

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