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FEBS Lett. 1993 Nov 15;334(2):203-9.

X-arrestin: a new retinal arrestin mapping to the X chromosome.

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Laboratory of Molecular Genetics, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33136.


We have been using a differential cDNA cloning approach to isolate human retina-specific and retina-enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina-specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine beta-arrestin, and bovine and human retinal arrestin (S-antigen), respectively. Chromosomal mapping localized this new arrestin gene to the proximal long arm of the X chromosome, hence it was named X-arrestin. In situ hybridization demonstrated its expression in the inner and outer segments and the inner plexiform regions of the retina.

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