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Eur J Pharmacol. 1993 Aug 3;239(1-3):265-6.

Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus.

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Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.


Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.

[Indexed for MEDLINE]

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