Format

Send to

Choose Destination
Cell. 1993 Nov 5;75(3):477-86.

Stepwise dismantling of adenovirus 2 during entry into cells.

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510.

Abstract

Adenoviruses enter their host cells by receptor-mediated endocytosis and acid-activated penetration from endosomes into the cytosol and deliver their DNA genome into the nucleus. Our results show that incoming adenovirus type 2 particles undergo a stepwise disassembly program necessary to allow progress of the virus in the entry pathway and release of the genome into the nucleus. The fibers are released, the penton base structures dissociated, the proteins connecting the DNA to the inside surface of the capsid degraded or shed, and the capsid-stabilizing minor proteins eliminated. The uncoating process starts immediately upon endocytic uptake with the loss of fibers and ends with the uptake of dissociated hexon proteins and DNA into the nucleus.

PMID:
8221887
DOI:
10.1016/0092-8674(93)90382-z
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Zurich Open Access Repository and Archive
Loading ...
Support Center