Statistical considerations for cross-sectional data relating to tracheal reconstruction over time

J Biopharm Stat. 1993 Sep;3(2):167-83. doi: 10.1080/10543409308835058.

Abstract

Complementary statistical analyses are performed on data concerning tracheal reconstruction in rats. The principal response criterion is vessel area as defined by the area of a graft onto the trachea covered by blood vessels. Postoperatively, this vessel area changes in a nonlinear fashion over time. Starting at 0% immediately postoperation, the vessel area increases to a peak and then sharply decreases to a certain level at which it remains. A total of 64 independently observed cross-sectional pairs (postop day, vessel area) are distributed among four treated groups. Analysis consists of two-way analysis of variance and piecewise linear regression under the usual assumptions of normality and variance homogeneity. Other analyses that relax these assumptions are also considered; treatment differences are established by nonparametric tests, and a quasi-likelihood analysis of the piecewise linear regression model is applied under the assumption of a binomial-like variance function. The resulting fit of the normal-theory-based piecewise linear model is compared to that of a nonlinear model whose shape is that of a gamma function integrand.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Cross-Sectional Studies*
  • Data Interpretation, Statistical*
  • Likelihood Functions
  • Linear Models
  • Models, Statistical*
  • Rats
  • Regression Analysis
  • Trachea / physiopathology*