[The distribution of hematoporphyrin derivatives in the animal body]

Eksp Klin Farmakol. 1993 Jul-Aug;56(4):48-50.
[Article in Russian]

Abstract

The pharmacokinetic distribution of haematoporphyrin derivative (HPD) and synthetic oligomeric haematoporphyrin (OG) which showed various lipophilicity was studied in animal tumor and normal tissues. The accumulation of dyes in tissue and their tumor-seeking capacity depended on the degree of polymerization, lipophilicity, and ratio of dye components. The difference in the absolute concentrations of HPD and OG (6.9 and 16.1 micrograms per g tissue, respectively) in tumor after dye injection in an adequate concentration (10 mg/kg b. w.) indicates that synthetic OG is beneficial for tumor diagnosis and photodynamic therapy.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Dihematoporphyrin Ether / analysis
  • Dihematoporphyrin Ether / pharmacokinetics
  • Hematoporphyrin Derivative / analysis
  • Hematoporphyrin Derivative / pharmacokinetics*
  • Neoplasm Transplantation
  • Rats
  • Reference Values
  • Sarcoma, Experimental / metabolism
  • Time Factors
  • Tissue Distribution

Substances

  • Hematoporphyrin Derivative
  • Dihematoporphyrin Ether