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Immunol Today. 1993 Sep;14(9):462-9.

Development in the thymus: it takes two to tango.

Author information

1
Dept of Immunology, Royal Postgraduate Medical School.

Abstract

Intrathymic T-cell development is dependent upon signals provided by the thymic stromal cell microenvironment. However, loss of thymic T cells in natural and experimentally induced situations is associated with a reduction in the surrounding epithelium, suggesting an interdependence between thymocytes and their microenvironment. Here, the authors review the evidence in favour of this intrathymic symbiosis, and hypothesize that T cells may provide maturation and survival signals that are necessary for the development and maintenance of their microenvironment.

PMID:
8216725
DOI:
10.1016/0167-5699(93)90250-O
[Indexed for MEDLINE]

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