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Biochem Biophys Res Commun. 1993 Oct 15;196(1):468-72.

Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene.

Author information

1
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Abstract

Drebrins are novel actin-binding proteins in the brain which are developmentally regulated. Three isoforms: two embryonic types (E1 and E2) and an adult type (A) are generated by alternative RNA splicing from a single debrin gene in the chicken brain. A full length cDNA clone of human drebrin E has been isolated from a cDNA library of human fetus brain. The clone is 2596 base pairs in length and contains an open reading frame of 1947 nucleotides encoding a protein of 649 amino acids. The deduced amino acid sequence, except for the internal 138-nucleotide sequence (ins2), exhibits 88% homology with rat drebrin A. Spot blot hybridization using flow-sorted human chromosomes provides evidence that the gene encoding human drebrin protein locates on human chromosome 5.

PMID:
8216329
DOI:
10.1006/bbrc.1993.2273
[Indexed for MEDLINE]

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