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Am Heart J. 1993 Oct;126(4):904-9.

Familial calcification of aorta and calcific aortic valve disease associated with immunologic abnormalities.

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1
Department of Cardiology, University of Athens, Hippokration Hospital, Greece.

Abstract

We report three patients of the same family with linear calcification of the ascending aorta, severe calcific mixed aortic valve disease associated with increased levels of globulins, lambda-chain gammopathy, an increased T4/T8 lymphocyte ratio, and other immunologic abnormalities. None of the patients had syphilis, atherosclerosis, abnormalities of calcium or phosphorus metabolism, lymphadenopathy, or other systemic diseases. It is postulated that these cases and some previously reported in the literature as idiopathic represent a distinct pathologic entity, familial or sporadic, in which localized vascular and valvular calcific disease is associated with an underlying immunologic disorder or autoimmune process.

PMID:
8213448
DOI:
10.1016/0002-8703(93)90705-e
[Indexed for MEDLINE]

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