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Vox Sang. 1993;65(2):156-7.

Haemolytic anaemia to the alpha-interferon treatment: a proposed mechanism.

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Department of Haematology-Haemotherapy, Fundación Jiménez Díaz, Madrid, Spain.


Auto-immune haemolytic anaemia (AIHA) has been found in a case of alpha-interferon treatment. Serum antibody and eluate were positive in the absence of the drug. Although the patient recovered after the treatment was stopped, DAGT remained positive for at least 8 months. The mechanism proposed to explain why this drug induced AIHA is similar to that proposed for alpha-methyl-dopa. Drugs could alter the red cell membrane and impair the immune system. Such changes have been observed with alpha-interferon and were related with increased autoimmunity.

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