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Science. 1993 Oct 1;262(5130):114-7.

Erythrocyte P antigen: cellular receptor for B19 parvovirus.

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1
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892.

Abstract

The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parvoviruses in gene therapy.

PMID:
8211117
[Indexed for MEDLINE]
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