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Ann Neurol. 1994 Jun;35(6):749-52.

Treatment of Guillain-Barré syndrome with high-dose immune globulins combined with methylprednisolone: a pilot study. The Dutch Guillain-Barré Study Group.

[No authors listed]

Erratum in

  • Ann Neurol 1994 Sep;36(3):457.


In an open study 25 patients with Guillain-Barré syndrome were treated for 5 days with intravenous immune globulins in a dose of 0.4 gm/kg of body weight/day and 0.5 gm of methylprednisolone intravenously per day. The results of this combined treatment were compared with the results from a group of 74 patients who were treated with immune globulins only in a recent Dutch Guillain-Barré trial. In the methylprednisolone-immune globulin treatment group, 19 of 25 patients (76%) improved by one or more functional grades after 4 weeks, as compared with 39 (53%) of 74 patients treated with immune globulin alone (p = 0.04). Also the median time required to the stage of walking independently was reduced in the methylprednisolone-immune globulin treatment group. This pilot study suggests that combined treatment with methylprednisolone and immune globulins in patients with the Guillain-Barré syndrome is more effective than treatment with immune globulins alone; a randomized clinical trial might confirm this.

[Indexed for MEDLINE]

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