Format

Send to

Choose Destination
Science. 1994 Jun 17;264(5166):1724-33.

Forward and reverse genetic approaches to behavior in the mouse.

Author information

1
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

Abstract

Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. "Reverse genetics" (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, "forward genetics" (from phenotype to gene) with high-efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.

Comment in

PMID:
8209253
PMCID:
PMC3830945
DOI:
10.1126/science.8209253
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center