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Life Sci. 1994;54(26):2055-9.

Antioxidant administration to the mother prevents oxidative stress associated with birth in the neonatal rat.

Author information

1
Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Spain.

Abstract

In the fetal-to-neonatal transition, important circulatory and respiratory changes ensue which lead to oxidative stress evidenced by changes in glutathione status. Administration of N-Acetyl-Cysteine (NAC), a glutathione precursor, to the mother might be a rational approach to protect the fetus against oxidative stress. We have found that NAC administration to pregnant rats partially prevents the change in hepatic GSSG that occurs in the fetal-neonatal transition: GSSG increased 11-fold (from 1 to 12 nmol/g) in controls and less than two-fold (from 5 to 9 nmol/g) in animals exposed to NAC in utero. The GSH/GSSG ratio in liver of NAC-treated newborns was 411 +/- 216 and in liver of controls it was 283 +/- 176. Thus, the oxidative stress that occurs in the fetal-to-neonatal transition is partially prevented by oral NAC administration.

PMID:
8208062
DOI:
10.1016/0024-3205(94)00714-4
[Indexed for MEDLINE]

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