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Gene. 1994 Jun 10;143(2):285-7.

A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII.

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1
Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854.

Abstract

A 1.2-kb cDNA clone isolated from a HeLa cell library contains an open reading frame encoding a new protein (p21) of 21 kDa that is approx. 48% similar to members of the eukaryotic transcription elongation factor SII (TFIIS) family. The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites.

PMID:
8206389
[Indexed for MEDLINE]
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