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FEBS Lett. 1994 Jun 6;346(1):17-20.

Specificity and promiscuity in membrane helix interactions.

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Department of Pharmacology, New York University Medical Center, NY 10016.


Transmembrane alpha-helices can associate with one another in lipid bilayers. This association is important in the folding and oligomerization of many integral membrane proteins, and may also play a role in their function. The interactions between helices may be highly specific or relatively non-specific, and their roles may differ accordingly. These two cases are discussed.

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