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Crit Care Med. 1994 Jun;22(6):930-8.

Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension.

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Cardiac Intensive Care Unit, Children's Hospital, Boston, MA 02115.



The development of a safe, portable, accurate, and adaptable system to deliver nitric oxide to patients with pulmonary hypertension.


A prospective, clinical study.


Tertiary care pediatric intensive care unit and cardiac catheterization laboratory.


One hundred twenty-three patients (median age 11 months, range 1 day to 72 yrs) with pulmonary hypertension who were administered nitric oxide between November 1991 and July 1993. Ninety-one patients were mechanically ventilated (volume-controlled ventilator, n = 53; pressure-controlled ventilator, n = 5; and a pressure-limited, time-cycled infant ventilator, n = 25). The system was adapted to allow high-frequency oscillator (n = 2) or hand ventilation, and for intraoperative use with an anesthesia machine (n = 6). Thirty-two patients were breathing spontaneously through a mask without assistance.


Nitric oxide was delivered at 10 to 80 parts per million (ppm); the dose was adjusted independently of the FIO2 without altering minute ventilation or tidal volume.


Nitrogen dioxide was continuously monitored and exceeded 3 ppm in only four patients. Methemoglobin concentrations were < 5% in all but four patients. Nitric oxide doses remained stable, independent of minute ventilation and could be changed easily and quickly.


Inhaled nitric oxide can be administered precisely and reliably through a variety of delivery systems which can be used in patients of any size. Potential toxicity requires careful monitoring and continued improvement on apparatus design.

[Indexed for MEDLINE]

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