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Cell. 1994 Jun 3;77(5):663-74.

A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering.

Author information

1
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University, California 94305.

Abstract

Synapse formation is characterized by the accumulation of molecules at the site of contact between pre- and postsynaptic cells. Agrin, a protein implicated in the regulation of this process, causes the clustering of acetylcholine receptors (AChRs). Here we characterize an agrin-binding site on the surface of muscle cells, show that this site corresponds to alpha-dystroglycan, and present evidence that alpha-dystroglycan is functionally related to agrin activity. Furthermore, we demonstrate that alpha-dystroglycan and adhalin, components of the dystrophin-associated glycoprotein complex, as well as utrophin, colocalize with agrin-induced AChR clusters. Thus, agrin may function by initiating or stabilizing a synapse-specific membrane cytoskeleton that in turn serves as a scaffold upon which synaptic molecules are concentrated.

PMID:
8205616
[Indexed for MEDLINE]

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