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Biochimie. 1993;75(12):1061-75.

Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.

Author information

1
Laboratoire de Biochimie, URA-CNRS no 240, Palaiseau, France.

Abstract

Methionine is the universal translation start but the first methionine is removed from most mature proteins. This review focuses on our present knowledge of the five enzymes sustaining the methionine pathway in translation initiation in Escherichia coli: methionyl-tRNA synthetase, methionyl-tRNA(fMet) formyltransferase, peptidyl-tRNA hydrolase, peptide deformylase and methionine aminopeptidase. The possible significance of retaining methionine as initiation signal is discussed.

PMID:
8199241
DOI:
10.1016/0300-9084(93)90005-d
[Indexed for MEDLINE]

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