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Biochem Biophys Res Commun. 1994 May 30;201(1):326-30.

Specificity of vascular endothelial cell growth factor receptor ligand binding domains.

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1
Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065.

Abstract

Vascular endothelial cell growth factor binds with high affinity to FLT and KDR, two homologous tyrosine kinase receptors expressed on vascular endothelial cells. Placental growth factor, a vascular endothelial cell growth factor homologue, also binds with high affinity to the extracellular domains of FLT but not to the extracellular region of KDR. Vascular endothelial cell growth factor binds competitively with placental growth factor to the extracellular ligand binding domains of FLT, indicating that both ligands probably complex to overlapping or identical regions of this receptor.

PMID:
8198591
DOI:
10.1006/bbrc.1994.1705
[Indexed for MEDLINE]
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