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Annu Rev Med. 1994;45:23-9.

Natural history of autosomal dominant polycystic kidney disease.

Author information

1
University of Colorado Health Sciences Center, Denver 80262.

Abstract

At least two different genes, which have been mapped to chromosomes 4 and 16, cause autosomal dominant polycystic kidney disease, a disorder with renal and extrarenal manifestations. Although gene-linkage testing is possible, the disease is diagnosed mainly through ultrasonography. Renal disease is characterized clinically by hypertension, acute and chronic pain, and variable progression to end-stage renal disease. Extrarenal manifestations include liver cysts, which may lead to complications; ruptured intracranial aneurysms; cardiac valvular disease; colonic diverticula; and inguinal hernias. Disease management is directed at minimizing and treating the complications of this illness.

PMID:
8198379
DOI:
10.1146/annurev.med.45.1.23
[Indexed for MEDLINE]

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