Send to

Choose Destination
Minerva Med. 1994 Mar;85(3):97-100.

[Fluoxetin combined with cyclobenzaprine in the treatment of fibromyalgia].

[Article in Italian]

Author information

II U.O. di Medicina Generale, USL n.9, Prato, Presidio Ospedaliero.


The aim of this study is to evaluate the effectiveness of fluoxetin associated with cyclobenzaprine vs cyclobenzaprine in the treatment of fibromyalgia. Twenty-one females with fibromyalgia were randomly assigned to 2 groups: group A (11 patients) was treated over 12 weeks with fluoxetin (20 mg/die) and cyclobenzaprine (10 mg/die), group B with cyclobenzaprine (10 mg/die). Basally and after 12 weeks patient self-assessment of pain, number of painful tender points, tender points index and morning stiffness were evaluated. The study has shown a significant improvement of the examined parameters in both treatment groups; however the comparison between the two groups showed a greater effectiveness, statistically significant, of the treatment with Fluoxetin associated with cyclobenzaprine.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center