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Eur J Pediatr. 1994 Apr;153(4):267-70.

Absence of cytochrome c oxidase activity in a boy with dysfunction of renal tubules, brain and muscle.

Author information

1
Department of Paediatric Nephrology and Metabolic Disorders, Children's Hospital, Hannover Medical School, Germany.

Abstract

We report on a boy who developed proximal renal tubular acidosis with loss of carnitine at the age of about 6 months. A few months later he began to suffer from progressive muscular weakness and neurological disturbances. Blood biochemistry showed elevated lactate and beta-hydroxybutyrate with increased lactate/pyruvate and beta-hydroxybutyrate/acetoacetate ratios. A high urinary excretion of lactate and citric acid cycle intermediates was found. These results indicated a defect of the mitochondrial respiratory chain. Analysis of biopsy material from skeletal muscle revealed low activities of all respiratory chain complexes. In muscle and fibroblasts cytochrome c-oxidase (complex IV) was absent. Despite high dose multi-vitamin therapy the boy died at the age of 30 months from central respiratory failure. At autopsy the neuropathological diagnosis of Leigh disease was made.

PMID:
8194561
[Indexed for MEDLINE]

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