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Curr Opin Genet Dev. 1994 Feb;4(1):96-101.

Ternary complex factors: growth factor regulated transcriptional activators.

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Transcription Laboratory, Imperial Cancer Research Fund, London, UK.


Members of a family of Ets domain proteins, the ternary complex factors (TCFs), are recruited to the c-fos serum response element by interaction with the serum response factor. Recent findings indicate that phosphorylation of TCFs occurs in response to activation of the MAP kinase pathway, and that regulation of TCF activity is an important mechanism by which the serum response element responds to growth factor signals.

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