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Curr Opin Genet Dev. 1994 Feb;4(1):71-6.

Activators and effectors of ras p21 proteins.

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Onyx Pharmaceuticals, Richmond, California 94806.


Over the past year, major advances have been made in understanding the key steps involved in signaling pathways--from receptor tyrosine kinases to ras p21, and on to a cascade of serine/threonine kinases. A chain of specific protein-protein interactions is responsible for signal transduction. Components of the pathway are highly conserved between flies, nematodes and mammals, and constitute a primary signaling device in most cell types.

[Indexed for MEDLINE]

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