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Curr Opin Genet Dev. 1994 Feb;4(1):47-54.

The IRS-1 signaling system.

Author information

1
Research Division, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215.

Abstract

IRS-1 is a principal substrate of the insulin receptor tyrosine kinase. It undergoes multi-site tyrosine phosphorylation and mediates the insulin signal by associating with various signaling molecules containing Src homology 2 domains. Interleukin-4 also stimulates IRS-1 phosphorylation, and it is suspected that a few more growth factors or cytokines will be added to form a select group of receptors that utilize the IRS-1 signaling pathway. More IRS-1-like adapter molecules, such as 4PS (IRS-2), may remain to be found.

PMID:
8193539
[Indexed for MEDLINE]

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