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Curr Opin Genet Dev. 1994 Feb;4(1):102-8.

Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

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Imperial Cancer Research Fund, London, UK.


The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for common DNA targets, and perhaps permit cellular differentiation.

[Indexed for MEDLINE]

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