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Trends Genet. 1994 Feb;10(2):44-8.

The 3Rs of life: Ras, Raf and growth regulation.

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  • 1Department of Cell Biology, Cleveland Clinic Foundation, OH 44195.

Abstract

Cellular Ras proteins are essential elements in normal signal transduction pathways while activated Ras proteins are prevalent in many different forms of human cancers. Here, we discuss the mechanism through which Ras proteins, either cellular or activated, transmit a proliferative signal by activating cytoplasmic serine/threonine kinases.

PMID:
8191584
[PubMed - indexed for MEDLINE]
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