Changes of myocardial myoglobin, myosin and creatine kinase in cases of sudden nocturnal death syndrome

Chin Med J (Engl). 1994 Jan;107(1):36-40.

Abstract

Myoglobin, myosin creatine kinase MM (CK-MM), creatine kinase BB(CK-BB) in cardiac muscle and H chain of myosin in atrial and ventricular muscle were studied in specimens from 8 patients who died of sudden nocturnal death syndrome (SNDS) by avidin-biotin complex (ABC) method to investigate the possible early or very early myocardial ischemia in the syndrome. Hematoxylin-eosin staining was conducted for comparison. The results showed evident loss of CK-MM, CK-BB, myoglobin and myosin from cardiac muscle cells, indicating that occurrence of SNDS is closely associated with acute myocardial ischemia.

MeSH terms

  • Adult
  • Creatine Kinase / metabolism*
  • Death, Sudden, Cardiac / etiology*
  • Humans
  • Immunoenzyme Techniques
  • Isoenzymes
  • Male
  • Middle Aged
  • Myocardial Ischemia / complications
  • Myocardial Ischemia / metabolism
  • Myocardium / metabolism*
  • Myoglobin / metabolism*
  • Myosins / metabolism*
  • Syndrome

Substances

  • Isoenzymes
  • Myoglobin
  • Creatine Kinase
  • Myosins