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Clin Rheumatol. 1994 Mar;13(1):75-9.

A clinical and biochemical assessment of methotrexate in rheumatoid arthritis.

Author information

1
Clinical Pharmacology Unit (Rheumatism Research) Royal Bath Hospital, North Yorkshire, United Kingdom.

Abstract

Low-dose methotrexate has gained widespread acceptance as a second-line agent in rheumatoid arthritis (RA). The Leeds Human Model Screening System (LHMSS) is a validated screening mechanism allowing the rapid evaluation of compounds for their potential as anti-rheumatic agents, the results of which have been confirmed in longer term studies. We have evaluated methotrexate in patients with RA using the LHMSS at a maintenance dose of 10mg/week. Significant change occurred in four out of eleven variables over a 24-week period (p < 0.01). This degree of change is greater than that seen with nonsteroidal anti-inflammatory agents but less than with other recognised second-line agents such as D-penicillamine, suggesting that methotrexate may have less potential as a second-line agent than D-penicillamine.

PMID:
8187448
DOI:
10.1007/bf02229869
[Indexed for MEDLINE]

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