Prophylactic endovascular radiotherapy to prevent intimal hyperplasia after stent implantation in femoropopliteal arteries

Cardiovasc Intervent Radiol. 1994 Jan-Feb;17(1):12-6.

Abstract

Purpose: Recurrent stenosis or occlusion by intimal hyperplasia occurs in up to 40% of patients with tantalum stent implantations in femoropopliteal arteries and greatly restricts their usefulness. We evaluated the effect of prophylactic endovascular radiotherapy on stenosed/occluded stents.

Methods: We investigated prophylactic endovascular radiotherapy with a surface dose of 12 Gy using an iridium 192 source as a means to reduce or eliminate recurrent stenosis in 4 patients with stenosed/occluded stents, 6-8 months after the original implantation. Confirmatory diagnostic atherectomy, PTA or laser recanalization and endovascular radiotherapy were performed.

Results: None of the four has developed recurrent obstruction within 23 to 30 months after this treatment, which up to now shows no short-term or long-term complications.

Conclusion: We conclude that this limited experience is promising enough to warrant further study.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Constriction, Pathologic / prevention & control
  • Female
  • Femoral Artery / pathology*
  • Femoral Artery / surgery
  • Humans
  • Hyperplasia / prevention & control
  • Male
  • Popliteal Artery / pathology*
  • Popliteal Artery / surgery
  • Postoperative Complications / prevention & control*
  • Radiotherapy / instrumentation
  • Radiotherapy / methods
  • Radiotherapy Dosage
  • Stents / adverse effects*
  • Tunica Intima / pathology*
  • Tunica Intima / radiation effects