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Biochem Pharmacol. 1994 Apr 29;47(9):1601-6.

Analysis of MRP mRNA in mitoxantrone-selected, multidrug-resistant human tumor cells.

Author information

1
Bone Marrow Transplant Program, Arizona Cancer Center, Tucson 85724.

Abstract

MRP, a gene recently isolated from a non-P-glycoprotein-mediated multidrug-resistant small cell lung cancer cell line, is a candidate multidrug-resistance gene. Mitoxantrone, an anthracenedione antitumor agent, frequently selects for non-P-glycoprotein-mediated multidrug resistance in in vitro models. To determine whether mitoxantrone-selected multidrug resistance was due to overexpression of MRP, we examined the expression of MRP in four mitoxantrone-selected, multidrug-resistant human tumor cell lines, using a reverse transcriptase/polymerase chain reaction assay. Results from these experiments suggest that overexpression of MRP does not appear to play a primary role in mitoxantrone-selected multidrug resistance in these cell lines, and that other novel drug-resistance mechanisms are likely.

PMID:
8185674
DOI:
10.1016/0006-2952(94)90538-x
[Indexed for MEDLINE]

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