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Biochem Biophys Res Commun. 1994 May 16;200(3):1271-6.

The phosphorylated forms of the transcription factor, Egr-1, bind to DNA more efficiently than non-phosphorylated.

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La Jolla Cancer Research Foundation, Ca 92037.


The transcription factor, Early growth response-1, Egr-1, occurs in several forms differing in length due to three alternate translation start sites (1). Egr-1 has also been reported to be phosphorylated although a role for this modification is unknown. Using dephosphorylation and hyperphosphorylation studies, we show here that phosphorylated Egr-1 is much more efficiently bound to its DNA binding element (GCE) and binds in a dose-dependent fashion. Egr-1 plays complex roles in growth regulation and we suggest that alternate forms of phosphorylated Egr-1 may account for this.

[Indexed for MEDLINE]

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