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Nature. 1994 May 19;369(6477):242-5.

A two-component system that regulates an osmosensing MAP kinase cascade in yeast.

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Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.


In the prokaryotic two-component signal transduction systems, recognition of an environmental stimulus by a sensor molecule results in the activation of its histidine kinase domain and phosphorylation of a histidine residue within that domain. This phosphate group is then transferred to an aspartate residue in the receiver domain of a cognate response regulator molecule, resulting in the activation of its output function. Although a few eukaryotic proteins were identified recently that show sequence similarity to the prokaryotic sensors or response regulators, it has not been clear whether they constituted a part of a 'two-component' system. Here we describe a two-component system in Saccharomyces cerevisiae that regulates an osmosensing MAP kinase cascade.

[Indexed for MEDLINE]

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