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J Rheumatol. 1994 Feb;21(2):220-3.

Lipoprotein(a) levels in systemic lupus erythematosus.

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1
Rheumatology Division, University Medical School Hospital, São Paulo, Brazil.

Abstract

OBJECTIVE:

To determine lipoprotein(a) [Lp(a)] levels in systemic lupus erythematosus (SLE) and its possible correlation with thrombosis, disease activity, anticardiolipin antibodies (aCL) and steroid therapy.

METHODS:

Serum Lp(a) levels were determined by radioimmunoassay (RIA) in 34 Caucasian patients with SLE and compared to 66 healthy subjects.

RESULTS:

In patients with SLE Lp(a) levels were higher than in controls (42 +/- 35 vs 26 +/- 25 mg/dl, p = 0.01). Lp(a) levels were high (> or = 30 mg/dl) in 56% of the patients with SLE and in 30% of controls (p = 0.02) but were not correlated with the clinical and laboratory findings.

CONCLUSIONS:

Lp(a) levels are significantly higher in patients with SLE and are not influenced by disease activity, thrombosis, aCL and steroid therapy.

PMID:
8182628
[Indexed for MEDLINE]
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