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Int J Cancer. 1994 May 15;57(4):529-31.

Inhibition of tumour promotion by various palm-oil tocotrienols.

Author information

1
Department of Chemistry, University of Malaya, Kuala Lumpur.

Abstract

Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that gamma- and delta-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). However, alpha- and gamma-tocopherols and dimers of gamma-tocotrienol or gamma-tocopherol lack this activity.

PMID:
8181855
[Indexed for MEDLINE]

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