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FEMS Microbiol Lett. 1994 Mar 15;117(1):15-9.

Serotyping Coxiella burnetii isolates from acute and chronic Q fever patients by using monoclonal antibodies.

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Unité des Rickettsies, Faculté de Medécine, CNRS EP J 0054, Marseille, France.


Four mouse monoclonal antibodies reacting with Coxiella burnetti lipopolysaccharide antigens were produced and used in serotyping 17 C. burnetii isolates from acute Q fever and Q fever endocarditis patients in France. Two monoclonal antibodies (1B2 and 3B6) were considered specific for the Priscilla strain, a representative of Q fever endocarditis isolates, and did not react with the Nine Mile strain, which is representative of acute Q fever isolates. Monoclonal antibodies Nos. 1B2 and 3B6 reacted with 75% (3/4) acute Q fever isolates and 85% (11/13) of endocarditis isolates from France. It is reasonable to conclude that Priscilla-like strains cause both acute Q fever and Q fever endocarditis. The hypothesis that Priscilla-like strains only are associated with Q fever endocarditis should be reconsidered.

[Indexed for MEDLINE]

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