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Arch Dermatol. 1994 May;130(5):605-8.

Macrophages and tumor necrosis factor alpha in toxic epidermal necrolysis.

Author information

1
Department of Dermatopathology, University of Liège, Belgium.

Abstract

BACKGROUND:

We studied the immunopathologic characteristics of five cases of toxic epidermal necrolysis by using a large panel of antibodies.

OBSERVATIONS:

The pattern and amount of the inflammatory cell infiltrate varied according to the stage of the disease. The main constant feature was the prominent involvement of the monocyte-macrophage lineage, including factor XIIIa+HLA-DR+ dendrocytes and CD68+ Mac 387+ macrophages, before and during the epidermal necrosis. The number of CD4+ and CD8+ lymphocytes was comparatively small. This was associated with a dense labeling of the epidermis for tumor necrosis factor alpha.

CONCLUSIONS:

Cells of the monocyte-macrophage lineage largely outnumber lymphocytes in the lesions of toxic epidermal necrolysis. Tumor necrosis factor alpha is likely a major cytokine that is responsible for necrosis.

PMID:
8179342
[Indexed for MEDLINE]

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