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Virology. 1994 May 1;200(2):809-12.

The stem-loop structure of the cis-encapsidation signal is highly conserved in naturally occurring hepatitis B virus variants.

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1
Department of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Abstract

The region encoding the stem-loop structure of the HBV cis-encapsidation signal was sequenced in 87 patients with various forms of hepatitis. Altogether, 20 nucleotide substitutions were found; 15/20 were predicted to increase the stability of the stem-loop structure. Substitutions likely to decrease the stability of the cis-encapsidation signal were not observed.

PMID:
8178463
DOI:
10.1006/viro.1994.1247
[Indexed for MEDLINE]

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