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Nature. 1994 May 12;369(6476):113-20.

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes.

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8002.

Abstract

Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.

PMID:
8177316
DOI:
10.1038/369113a0
[Indexed for MEDLINE]

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