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Fertil Steril. 1994 May;61(5):911-4.

Tamoxifen treatment in male infertility. I. Effect on spermatozoa.

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1
Department of Gynecology, General Hospital of Athens, Greece.

Abstract

OBJECTIVE:

To evaluate the effects of tamoxifen treatment on sperm density, motility, vitality, and morphology.

DESIGN:

Placebo-controlled, randomized study.

SETTING:

Outpatient department.

INTERVENTIONS:

Patients were assigned to two comparable groups: group A (n = 122) was treated with 10 mg tamoxifen twice daily for a period of 3 months and group B (n = 117) was given placebo for the same period of time, following a previously randomized design.

MAIN OUTCOME MEASURES:

In every patient sperm density, motility, viability, and morphology were evaluated 3 months after cessation of treatment.

RESULTS:

Mean sperm density in group A improved significantly with a more pronounced improvement in severe oligozoospermic men. Sperm density was found significantly improved compared with group B. Dead spermatozoa in group A significantly decreased after tamoxifen treatment and were also found significantly decreased compared with group B.

CONCLUSION:

It is concluded that tamoxifen exerts a beneficial effect on sperm density and number of live spermatozoa but it has no substantial effect in sperm motility and morphology.

PMID:
8174730
[Indexed for MEDLINE]

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