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Curr Opin Immunol. 1994 Feb;6(1):3-8.

B cell antigen receptors.

Author information

1
Max-Planck Institut für Immunbiologie, Freiburg, Germany.

Abstract

Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen receptor is functionally divided into the ligand-binding immunoglobulin (Ig) molecule and the signal-transducing Ig-alpha/Ig-beta heterodimer. This knowledge has been exploited to design variant antigen receptors which combine both functions in a single molecule.

PMID:
8172677
DOI:
10.1016/0952-7915(94)90026-4
[Indexed for MEDLINE]

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