Format

Send to

Choose Destination
Am J Gastroenterol. 1994 May;89(5):708-11.

Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease.

Author information

1
Department of Internal Medicine, University of Nebraska Medical Center, Omaha.

Abstract

OBJECTIVES:

To evaluate gastric emptying in patients with chronic liver disease and portal hypertension.

METHODS:

We measured gastric emptying of both the liquid and solid components of a meal in 10 consecutive patients with chronic liver disease and portal hypertension, but free of ascites, and 14 age- and sex-matched healthy controls. In the patients with liver disease, relationships between emptying and liver function were examined. To measure gastric emptying, subjects consumed a test meal that consisted of scrambled eggs labeled with 99mTc-sulfur colloid and 4 oz of water labeled with 111In-diethylene triamine pentacetic acid (DTPA).

RESULTS:

Patients with liver disease and portal hypertension demonstrated delayed emptying of both the liquid (t1/2, min, mean +/- SE, patients vs.

CONTROLS:

69.4 +/- 19.4 vs. 31.4 +/- 1.8, p < 0.01) and solid (post-lag phase solid emptying: 141 +/- 32.9 vs. 69.8 +/- 4.6, p < 0.006) components of the meal. We could not identify any correlation between gastric emptying and tests of liver function.

CONCLUSIONS:

Gastric emptying is delayed in patients with liver disease and portal hypertension; this abnormal gastric motor function may contribute to the pathophysiology of foregut complaints in this patient population.

PMID:
8172142
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center