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Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jan-Feb;44(1):85-90.

[The participation of adrenoreceptors in regulating dominant behavior and gonadal endocrine function in male mice of different genotypes].

[Article in Russian]


Dominant behaviour and testosterone level were investigated after adrenoreceptor (AR) blocking drugs injections in PT and CBA/Lac mice predisposed, correspondingly, to dominant and subordinate behaviour in a population and their hybrids F1. Phentolamine (alpha-AR blocker, 1 mg/kg) or obsidan (beta-AR blocker, 1 mg/kg) injections resulted in a loss of the dominant rank of CBA/Lac mice and did not affect the PT mice behaviour. Higher doses (2 and 5 mg/kg) were also ineffective. Simultaneous phentolamine and obsidan injections (1 mg/kg) caused a dominant phenotype inversion, decrease of aggression and testosterone level in PT mice. F1 inherited an ability to dominate in a population and a sensitivity of AR form PT inbred strain. Their behaviour and endocrine characteristics after injections of AR-blockers were close to those of PT mice.

[Indexed for MEDLINE]

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