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Biochem Biophys Res Commun. 1994 Apr 15;200(1):642-6.

Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.

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First Department of Internal Medicine, Miyazaki Medical College.


A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 x 10(-9) M). In a receptor binding assay for AM in rat VSMC, the binding of [125I] AM was competitively inhibited by human AM, but not by human CGRP. Thus, AM is thought to increase intracellular cAMP in rat VSMC via its specific receptor to evoke vasodilation.

[Indexed for MEDLINE]

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