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Am J Pediatr Hematol Oncol. 1994 May;16(2):156-9.

Treatment of refractory Evans syndrome with alternate-day cyclosporine and prednisone.

Author information

1
Section of Pediatric Hematology-Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202-5225.

Abstract

PURPOSE:

We report that the use of alternate-day cyclosporine and prednisone improved the clinical course of a 6-year-old child with severe Evans syndrome. Before the use of cyclosporine the child had experienced life-threatening episodes of hemolytic anemia despite the use of multiple therapeutic modalities.

METHODS:

Cyclosporine was given at a dose of 10 mg/kg/day divided into two doses on alternate days.

RESULTS:

The use of cyclosporine resulted in increased hemoglobin levels, increased platelet counts, and the reduction of the patient's prednisone dose from 2 mg/kg/day to as low as 1 mg/kg every other day. With this regimen, the patient had less severe hemolytic anemia, was less thrombocytopenic, and had fewer hospitalizations. No major toxic effects were associated with cyclosporine therapy.

CONCLUSION:

The regimen of alternate-day cyclosporine and prednisone may prove to be useful in the treatment of other patients with refractory Evans syndrome.

PMID:
8166369
[Indexed for MEDLINE]

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