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Trends Microbiol. 1994 Feb;2(2):39-43.

Host cell proteases controlling virus pathogenicity.

Author information

1
Institut für Virologie, Philipps-Universität Marburg, Germany.

Abstract

The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.

PMID:
8162439
DOI:
10.1016/0966-842x(94)90123-6
[Indexed for MEDLINE]

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